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KMID : 1037120220400020340
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The World Journal of Men′s Health
2022 Volume.40 No. 2 p.340 ~ p.343
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SARS-CoV-2 in the Prostate: Immunohistochemical and Ultrastructural Studies
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Reddy Rohit
Farber Natoli
Kresch Eliyahu
Seetharam Deepa
Diaz Parris
Ramasamy Ranjith
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Abstract
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The novel coronavirus SARS-CoV-2 was discovered in 2019 and has proven to be a significant public health challenge. While viruses from the coronavirus family have been established as causes of respiratory tract infections, SARS-CoV-2 has also been found in the heart, kidney, testes, and penis. This paper investigates whether SARS-CoV-2 can linger in the prostate by examining the histopathological, ultrastructural, and immunofluorescent elements of prostatic tissue from a patient who was infected by the SARS-CoV-2 virus prior to having a holmium laser enucleation of the prostate (HoLEP) procedure. The findings of this case report suggest that COVID-19 has both the ability to enter prostatic tissue during an acute infection and persist over a timeframe beyond the initial infection period as RNA-containing viral bodies. This case report lays the foundation for future investigations to examine any histopathological changes to the prostatic tissue that may be associated with SARS-CoV-2 viral infection.
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KEYWORD
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COVID-19, Microscopy, electron, Prostate, Prostatic hyperplasia, SARS-CoV-2
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